id: Pfam:PF05871
pfam_id: PF05871
name: ESCRT-II complex subunit
short_name: ESCRT-II
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05871
counters:
  proteins: 3782
  matches: 3804
  proteomes: 3214
  taxa: 8677
  structures: 8
  alphafold_models: 3245
  domain_architectures: 83
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008570
description: This family of conserved eukaryotic proteins are subunits of the endosome associated complex
  ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB) [[cite:PUB00019520]].
  This protein complex transiently associates with the endosomal membrane and thereby initiates the formation
  of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II
  during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that
  binds to ubiquitinated endosomal cargo [[cite:PUB00019520]].