id: Pfam:PF05872
pfam_id: PF05872
name: Helicase HerA-like C-terminal
short_name: HerA_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05872
counters:
  proteins: 8459
  matches: 8512
  proteomes: 8043
  taxa: 11029
  structures: 8
  alphafold_models: 5303
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR033186
description: HerA is a DNA helicase able to utilise either 3' or 5' single-stranded DNA extensions for
  loading and subsequent DNA duplex unwinding [[cite:PUB00076694]]. It forms a complex with NurA nuclease,
  this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon
  Sulfolobus islandicus [[cite:PUB00076695]]. This entry represents the C-terminal domain of HerA which
  seems to be involved in the conversion of ATP hydrolysis into DNA translocation [[cite:PUB00078094]].