id: Pfam:PF05891
pfam_id: PF05891
name: AdoMet dependent proline di-methyltransferase
short_name: Methyltransf_PK
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05891
counters:
  proteins: 5051
  matches: 5426
  proteomes: 3284
  taxa: 8737
  structures: 25
  alphafold_models: 4329
  domain_architectures: 101
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008576
description: This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base].
  In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyses
  the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases
  described here specifically recognise the N-terminal X-Pro-Lys sequence motif, and they may account
  for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of
  other yeast and human proteins also share the recognition motif and may be similarly modified [[cite:PUB00073462]].
  As with other methyltransferases, this family carries the characteristic GxGxG motif.