id: Pfam:PF05903
pfam_id: PF05903
name: PPPDE putative peptidase domain
short_name: Peptidase_C97
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05903
counters:
  proteins: 13767
  matches: 13857
  proteomes: 3325
  taxa: 8933
  structures: 2
  alphafold_models: 11440
  domain_architectures: 274
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008580
description: The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes),
  consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of
  the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain
  to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain,
  after PLAP, Ufd3p and Lub1p) [[cite:PUB00020916]].