id: Pfam:PF05907
pfam_id: PF05907
name: CXXC motif containing zinc binding protein, eukaryotic
short_name: CXXC_Zn-b_euk
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05907
counters:
  proteins: 4114
  matches: 4217
  proteomes: 3282
  taxa: 8697
  structures: 7
  alphafold_models: 3535
  domain_architectures: 76
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008584
description: This family consists of a number of eukaryotic proteins including CXXC motif containing zinc
  binding protein (previously known as UPF0587 protein C1orf123). The crystal structure reveals that the
  protein binds a Zn2+ ion in a tetrahedral coordination with four Cys residues from two CxxC motifs.
  CXXC motif containing zinc binding protein was initially identified as an interaction partner for the
  heavy metal-associated (HMA) domain of CCS (copper chaperone for superoxide dismutase). However, it
  was shown that only misfolded mutant forms, lacking part of the zinc-binding sites, interact with CCS
  [[cite:PUB00091677]].