id: Pfam:PF05913
pfam_id: PF05913
name: 6-phospho-N-acetylmuramidase, C-terminal
short_name: MupG_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05913
counters:
  proteins: 2025
  matches: 2025
  proteomes: 1279
  taxa: 2033
  structures: 2
  alphafold_models: 1344
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR043894
description: This entry represents the C-terminal domain of 6-phospho-N-acetylmuramidase (MupG) found
  in bacteria. It characterises putative phospho sugar glycosidases found in Gram-negative and -positive
  species, but mainly in firmicutes. MupG from Staphylococcus aureus [[cite:PUB00097906]], specifically
  cleaves MurNAc 6P-GlcNAc, a product of cell wall turnover, into the sugars MurNAc 6P and GlcNAc, being
  involved in cell wall turnover and recycling. Since some species, for example Lactobacillus plantarum,
  possess several putative paralogs, the substrate specificity of these proteins may not be limited to
  cell wall sugars, but may include phosphorylated disaccharides in general. Most proteins containing
  this domain appear to consist of two structural subdomains, as it can be seen in the two available crystal
  structures of Enterococcus faecalis (PDB:2p0o) and Bacillus cereus (PDB:1X7F). The larger N-terminal
  domain constitutes a TIM-barrel like structure and the C-terminal domain (this entry) is similar to
  the cyclophilin family. It should be noted that some proteins lack this domain.