id: Pfam:PF05916
pfam_id: PF05916
name: GINS complex protein helical bundle domain
short_name: Sld5
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05916
counters:
  proteins: 13691
  matches: 13694
  proteomes: 3614
  taxa: 9502
  structures: 51
  alphafold_models: 11723
  domain_architectures: 205
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021151
description: This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex
  is essential for the initiation and elongation phases of DNA replication [[cite:PUB00012381],[cite:PUB00015004],[cite:PUB00152224]].
  It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included
  in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind
  directly to DNA primase [[cite:PUB00109209]].