id: Pfam:PF05962
pfam_id: PF05962
name: HutD
short_name: HutD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05962
counters:
  proteins: 4240
  matches: 4267
  proteomes: 3945
  taxa: 5441
  structures: 3
  alphafold_models: 2442
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010282
description: HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation
  operon. HutD is operonic with the well characterised repressor protein HutC. Genetic analysis using
  transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness
  in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD
  functions as a governor that sets an upper bound on the level of hut operon transcription [[cite:PUB00044765]].
  The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure
  of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine)
  docks with the active site of HutD.