id: Pfam:PF05971
pfam_id: PF05971
name: RNA methyltransferase
short_name: Methyltransf_10
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05971
counters:
  proteins: 7120
  matches: 7961
  proteomes: 6099
  taxa: 12386
  structures: 31
  alphafold_models: 5338
  domain_architectures: 87
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010286
description: This family includes ribosomal RNA large subunit methyltransferase F, and related proteins,
  including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase
  which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localisation [[cite:PUB00085149]].
  Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the
  SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown
  methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional
  function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase
  gene expression [[cite:PUB00086421]].