id: Pfam:PF05978
pfam_id: PF05978
name: Ion channel regulatory protein UNC-93
short_name: UNC-93
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05978
counters:
  proteins: 11159
  matches: 11823
  proteomes: 2949
  taxa: 8050
  structures: 0
  alphafold_models: 9617
  domain_architectures: 156
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010291
description: The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also
  includes protein unc-93 homologue A (UNC93A), protein unc-93 homologue B1 (UNC93B1), and UNC93-like
  protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET).
  UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of
  a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C.
  elegans [[cite:PUB00053696]]. UNC93B1 controls intracellular trafficking and transport of a subset of
  Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes
  where they can engage pathogen nucleotides and activate signaling cascades [[cite:PUB00097046]]. MFSD11
  is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed
  in excitatory and inhibitory mouse brain neurons [[cite:PUB00097045]].