id: Pfam:PF05991
pfam_id: PF05991
name: YacP-like NYN domain
short_name: NYN_YacP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05991
counters:
  proteins: 6344
  matches: 6405
  proteomes: 5929
  taxa: 9190
  structures: 2
  alphafold_models: 4095
  domain_architectures: 33
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010298
description: This family consists of bacterial proteins related to YacP. This family is uncharacterised
  functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN
  domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind [[cite:PUB00056584]].
  Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease
  III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA [[cite:PUB00056584]].