id: Pfam:PF06005
pfam_id: PF06005
name: ZapB family
short_name: ZapB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06005
counters:
  proteins: 1534
  matches: 1534
  proteomes: 1468
  taxa: 2333
  structures: 1
  alphafold_models: 1054
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009252
description: The ZapB family consists of non-essential, abundant cell division proteins that play a crucial
  role in the formation of the Z-ring during bacterial cell division. These proteins are recruited early
  to the divisome through direct interaction with FtsZ, a key protein in the assembly of the Z-ring. By
  stimulating Z-ring assembly, ZapB proteins promote cell division earlier in the cell cycle. Their recruitment
  to the Z-ring is dependent on the presence of functional FtsA or ZipA proteins. Structurally, ZapB proteins
  form homodimers, with the ends of the coiled-coil dimers binding to each other to form polymers. This
  polymerization is essential for their function in cell division [[cite:PUB00078060]].