id: Pfam:PF06030
pfam_id: PF06030
name: WxL Interacting Protein, peptidoglycan binding domain
short_name: WxLIP_PGBD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06030
counters:
  proteins: 2046
  matches: 2047
  proteomes: 599
  taxa: 1011
  structures: 2
  alphafold_models: 1299
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010317
description: 'This domain (previously known as DUF916) is found in WxL interacting proteins (WxLIP) which
  play a role in virulence and are widely distributed in firmicutes. The WxL proteins usually occur within
  a gene cluster that contains two WxL proteins and a WxL interacting protein composed of three domains:
  peptidoglycan binding domain (PGBD), host binding domain (HBD), and transmembrane helix (TMH). The domain
  represented by this entry is involved in binding to peptidoglycan and to WxL, and anchoring the protein
  cluster onto the bacterial surface. This PGBD domain is frequently found in combination with HBD domain
  ([pfam:PF11797]) and both were shown to function synergistically as a single unit that binds to the
  peptidoglycan and interacts with the eukaryotic host [[cite:PUB00154331]]. The PGBD domain is predicted
  to adopt a beta-sandwich with an Ig-like topology.'