id: Pfam:PF06047
pfam_id: PF06047
name: NF-kappa-B-activating protein C-terminal domain
short_name: Nkap_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06047
counters:
  proteins: 2915
  matches: 2925
  proteomes: 2230
  taxa: 6580
  structures: 4
  alphafold_models: 2470
  domain_architectures: 67
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009269
description: This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical
  open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is
  the HDAC3 binding domain and is required for transcriptional repression [[cite:PUB00075800]]. Nkap functions
  as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition
  of functional competency [[cite:PUB00075800],[cite:PUB00075801],[cite:PUB00075802]].