id: Pfam:PF06106
pfam_id: PF06106
name: S. aureus uracil DNA glycosylase inhibitor
short_name: SAUGI
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06106
counters:
  proteins: 101
  matches: 101
  proteomes: 36
  taxa: 65
  structures: 8
  alphafold_models: 79
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009295
description: Uracil-DNA glycosylase inhibitors, are DNA mimic proteins that prevent the DNA binding sites
  of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 [swissprot:Q4A134]
  (or SAUGI; for Staphylococcus aureus uracil-DNA glycosylase inhibitor) acts as a uracil-DNA glycosylase
  inhibitor that breaks the uracil-removing activity of S. aureus uracil-DNA glycosylase (SAUDG) [pfam:PF03167]
  [[cite:PUB00085049]]. The SAUGI/SAUDG complex has been determined, and shows that SAUGI binds to the
  SAUDG DNA binding region via several strong interactions, by using a hydrophobic pocket to hold SAUDG's
  protruding residue (i.e. SAUDG Leu184, E. coli UDG Leu191 and B. subtilis UDG Phe191). By binding to
  SAUDG in this way, SAUGI thus prevents SAUDG from binding to its DNA substrate and performing DNA repair
  activity [[cite:PUB00085050]].