id: Pfam:PF06133
pfam_id: PF06133
name: Control of competence regulator ComK, YlbF/YmcA
short_name: Com_YlbF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06133
counters:
  proteins: 6153
  matches: 6154
  proteomes: 2937
  taxa: 4407
  structures: 6
  alphafold_models: 4127
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010368
description: YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and
  YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null
  mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as
  smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, [pfam:PF04468],
  interact directly with one another forming a stable ternary complex, in vitro. All three proteins are
  required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects
  the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three
  processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated
  form of Spo0A, as Spo0A-P [[cite:PUB00075458],[cite:PUB00075459]].