id: Pfam:PF06135
pfam_id: PF06135
name: IreB regulatory phosphoprotein
short_name: IreB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06135
counters:
  proteins: 3249
  matches: 3249
  proteomes: 3142
  taxa: 4669
  structures: 4
  alphafold_models: 2214
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009309
description: IreB is a cytosolic 10.5-kDa protein that is highly conserved among low-GC Gram-positive
  bacteria . Studies of E. faecalis mutants lacking ireB revealed that IreB acts downstream of IreK as
  a negative regulator of cephalosporin resistance in E. faecalis. IreB can be modified by phosphorylation
  in vivo, and mutations that prevent modification at the known sites of phosphorylation (T4 and T7) influence
  the ability of IreB to modulate cephalosporin resistance. Furthermore, mutations that impair dimerization
  abolish the regulation of cephalosporin resistance [[cite:PUB00091063]].