id: Pfam:PF06167
pfam_id: PF06167
name: Glucose-regulated metallo-peptidase M90
short_name: Peptidase_M90
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06167
counters:
  proteins: 4702
  matches: 4705
  proteomes: 4323
  taxa: 6130
  structures: 2
  alphafold_models: 2921
  domain_architectures: 11
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010384
description: MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies),
  itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase
  (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found
  to bind and inactivate Mlc with high affinity [[cite:PUB00054592]]. The membrane-bound protein EIICBGlc
  encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a
  glucose-regulated peptidase [[cite:PUB00066805]], whose activity is regulated by binding to Mlc available
  in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken
  up. A physiologically relevant target for this peptidase is not yet known.