id: Pfam:PF06224
pfam_id: PF06224
name: DNA glycosylase AlkZ-like
short_name: AlkZ-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06224
counters:
  proteins: 16955
  matches: 17024
  proteomes: 7771
  taxa: 10387
  structures: 2
  alphafold_models: 9642
  domain_architectures: 19
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009351
description: This protein family includes DNA glycosylase AlkZ from Streptomyces sahachiroi (also known
  as Azi36) and similar proteins predominantly found in bacteria. AlkZ is an enzyme that provides self-resistance
  from azinomycin B (AZB) toxicity by unhooking interstrand cross- links (ICLs). The crystal structure
  of AlkZ revealed a C-shaped configuration with three tandem winged helix-turn-helix (wHTH) motifs and
  a positively charged surface that shows residues of great importance for the enzymatic activity [[cite:PUB00100682]].