id: Pfam:PF06244
pfam_id: PF06244
name: Coiled-coil domain-containing protein 124 /Oxs1
short_name: Ccdc124
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06244
counters:
  proteins: 3669
  matches: 3679
  proteomes: 3093
  taxa: 8262
  structures: 5
  alphafold_models: 3137
  domain_architectures: 61
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR054414
description: Oxs1 (oxidative stress transcription corepressor Oxs1) and Pap1 form a complex to regulate
  transcription when cells are exposed to diamide or Cd that causes disulfide stress. In fission yeast
  such as S. pombe, heterologous Oxs1-like proteins can enhance diamide stress tolerance. Furthermore,
  human and arabidopsis Oxs1 can interchangeably bind Pap1 or Pap1 homologues from human (cJun) and arabidopsis
  (bZIP10), suggesting that Oxs1 may be a component of an evolutionarily-conserved stress response pathway
  [[cite:PUB00091062]]. Family members found in human such as Ccdc124 (Coiled-Coil Domain Containing Protein
  124), were identified as a novel component of the centrosome during interphase and G2/M transition and
  is involved in cytokinesis [[cite:PUB00091062],[cite:PUB00073830]].