id: Pfam:PF06250
pfam_id: PF06250
name: YhcG PDDEXK nuclease domain
short_name: YhcG_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06250
counters:
  proteins: 4815
  matches: 4819
  proteomes: 2895
  taxa: 4985
  structures: 0
  alphafold_models: 3190
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009362
description: This domain can be found in uncharacterised proteins in viruses, archaea and bacteria, most
  notably it is found in YhcG proteins found in E.coli. This entry represents the C-terminal PDDEXK domain
  belonging to the PD-(D/E)XK superfamily of nucleases involved in DNA recombination and repair [[cite:PUB00091061]].
  Profile HMM analysis identified a relationship between this C-terminal domain of YhcG and [pfam:PF01939]
  , a family of NucS endonucleases [[cite:PUB00054003]]. YHcG was identified in association with DNA processing
  enzymes, including the restriction complexes HsdMRS and McrABC, the integrases IntF and IntS, and the
  recombinase PinE [[cite:PUB00091061]].