id: Pfam:PF06252
pfam_id: PF06252
name: Bacteriophage Mu, GemA protein
short_name: GemA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06252
counters:
  proteins: 1310
  matches: 1312
  proteomes: 1041
  taxa: 2192
  structures: 0
  alphafold_models: 854
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009363
description: This family consists of several bacterial and phage proteins, including GemA (also known
  as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA
  gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of
  various host genes probably controlled by supercoiling of their promoters. Host genes affected include
  DNA replication and cell division determinants [[cite:PUB00097481]]. This family also includes the Mu-like
  prophage FluMu protein gp16 from Haemophilus influenzae.