id: Pfam:PF06257
pfam_id: PF06257
name: Biofilm formation stimulator VEG
short_name: VEG
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06257
counters:
  proteins: 2633
  matches: 2633
  proteomes: 2624
  taxa: 3732
  structures: 1
  alphafold_models: 1775
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009366
description: VEG is a family that is highly conserved among Gram-positive bacteria. It stimulates biofilm
  formation through inducing transcription of the tapA-sipW-tasA operon. The products of this operon are
  resposible for production of the amyloid fibre (TasA) component of the biofilm. Veg or a Veg-induced
  protein acts as an antirepressor of SinR - part of the major overall biofilm transcriptional control
  system - to regulate and stimulate biofilm formation. Veg is transcribed at high levels during both
  exponential growth and sporulation [[cite:PUB00070838],[cite:PUB00070839]].