id: Pfam:PF06292
pfam_id: PF06292
name: MUN domain
short_name: MUN
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06292
counters:
  proteins: 17631
  matches: 22932
  proteomes: 2603
  taxa: 7010
  structures: 12
  alphafold_models: 6555
  domain_architectures: 159
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010439
description: This entry corresponds to the MUN domain [[cite:PUB00097712]] found in Munc13 proteins. These
  constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology
  to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two
  C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions
  called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains.
  MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans,
  Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to
  regulate membrane trafficking. Structural studies have defined MHD1 and MHD2 to be part of the larger
  MUN domain which forms an elongated structure composed of any pairs of alpha helices.