id: Pfam:PF06294
pfam_id: PF06294
name: CH-like domain in sperm protein
short_name: CH_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06294
counters:
  proteins: 3966
  matches: 3973
  proteomes: 1198
  taxa: 3948
  structures: 8
  alphafold_models: 2630
  domain_architectures: 80
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010441
description: Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis
  in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing
  and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum
  [[cite:PUB00044949]]. The amino-terminal domain (residues 1-110) shows a possible calponin homology
  (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of
  the amino-terminal calponin-like domain is unclear [[cite:PUB00044949]]. Transcription aberrations leading
  to a truncated protein result in immotile sperm [[cite:PUB00044950]].