id: Pfam:PF06303
pfam_id: PF06303
name: MatP N-terminal domain
short_name: MatP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06303
counters:
  proteins: 896
  matches: 896
  proteomes: 844
  taxa: 1220
  structures: 9
  alphafold_models: 608
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR035087
description: 'This family, many of whose members are YcbG, organises the macrodomain Ter of the chromosome
  of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister
  chromatids and the mobility of chromosomal DNA. Organisation of the Terminus region (Ter) into a macrodomain
  relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS
  sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP
  accumulates in the cell as a discrete focus that co-localises with the Ter macrodomain. The effects
  of MatP inactivation reveal its role as the main organiser of the Ter macrodomain: in the absence of
  MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain
  occurs early in the cell cycle. A specific organisational system is required in the Terminus region
  for bacterial chromosome management during the cell cycle. This entry represents the N-terminal domain
  of MatP.'