id: Pfam:PF06327
pfam_id: PF06327
name: Adenylate cyclase, conserved domain
short_name: Adcy_cons_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06327
counters:
  proteins: 8560
  matches: 8592
  proteomes: 1178
  taxa: 3902
  structures: 4
  alphafold_models: 6799
  domain_architectures: 63
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009398
description: 'Adenylate cyclase (AC) enzyme uses ATP as its substrate to produce Cyclic AMP (cAMP), a
  ubiquitous signalling molecule that mediates many cellular processes by activating cAMP- dependent kinases
  and also inducing protein-protein interactions. Mammalian adenylate cyclase has nine closely related
  membrane-bound isoforms (AC1-9) showing significant sequence homology and sharing the same overall structure:
  two hydrophobic transmembrane domains, and two cytoplasmic domains that are responsible for the catalytic
  activity. These isoforms differ in both their tissue specificity and their regulation [[cite:PUB00034664],[cite:PUB00034665]].
  This entry represents a region of unknown function found in many of these isoforms. It is part of the
  N-terminal cytoplasmic domain but its presence is not necessary for catalytic activity [[cite:PUB00034666]].'