id: Pfam:PF06378
pfam_id: PF06378
name: Sak Single Strand Annealing Protein
short_name: SSAP_Sak
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06378
counters:
  proteins: 269
  matches: 276
  proteomes: 247
  taxa: 555
  structures: 2
  alphafold_models: 99
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009425
description: This family represents the Sak Single Strand Annealing Protein (SSAP) from Staphylococcal
  Bacteriophage 80alpha which belongs to Rad52-like superfamily. The Sak protein from phage 80alpha shares
  similarities with other SSAPs, such as Red-beta from phage alpha and RAD52 from eukaryotes. SSAPs like
  Sak play a crucial role in homologous recombination by promoting the annealing of complementary single-stranded
  DNA. Sak adopts a similar to other SSAPs structure and shows the groove commonly seen in SSAPs to accommodate
  ssDNA in the outer surface of the torus, known as the ssDNA binding groove or ssDBG [[cite:PUB00160682]].