id: Pfam:PF06416
pfam_id: PF06416
name: Effector protein NleG
short_name: T3SS_NleG
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06416
counters:
  proteins: 39
  matches: 39
  proteomes: 13
  taxa: 49
  structures: 3
  alphafold_models: 28
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010489
description: Many bacterial pathogens deliver effector proteins into host cells via a type III secretion
  system. These effector proteins then alter the host cell's biology in ways that are advantageous to
  the pathogen. The NleG protein and its homologues form the largest family of effector proteins in the
  enterohemorrhagic Escherichia coli O157:H7, with 14 members identified in the Sakai strain alone [[cite:PUB00056590]].