id: Pfam:PF06417
pfam_id: PF06417
name: ER membrane protein complex subunit 4
short_name: EMC4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06417
counters:
  proteins: 3905
  matches: 3918
  proteomes: 3220
  taxa: 8600
  structures: 12
  alphafold_models: 3351
  domain_architectures: 81
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009445
description: This entry includes ER membrane protein complex subunit 4 (EMC4 also known as TMEM85 in mammals)
  from animals and its orthologue Emc4 from budding yeasts. They inhibit hydrogen peroxide mediated cell
  death in yeast [[cite:PUB00086405]]. Emc4 is part of the ER membrane complex (EMC) that enables the
  energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins
  [[cite:PUB00067575],[cite:PUB00096682],[cite:PUB00096681]].