id: Pfam:PF06452
pfam_id: PF06452
name: Carbohydrate family 9 binding domain-like
short_name: CBM9_1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06452
counters:
  proteins: 6161
  matches: 6400
  proteomes: 3332
  taxa: 5255
  structures: 7
  alphafold_models: 3453
  domain_architectures: 503
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010502
description: CBM9_1 is a C-terminal domain on bacterial xylanase proteins, and it is tandemly repeated
  in a number of family-members. The CBM9 module binds to amorphous and crystalline cellulose and a range
  of soluble di- and monosaccharides as well as to cello- and xylo- oligomers of different degrees of
  polymerisation. Comparison of the glucose and cellobiose complexes during crystallisation reveals surprising
  differences in binding of these two substrates by CBM9-2. Cellobiose was found to bind in a distinct
  orientation from glucose, while still maintaining optimal stacking and electrostatic interactions with
  the reducing end sugar [[cite:PUB00011788]].