id: Pfam:PF06454
pfam_id: PF06454
name: THH1/TOM1/TOM3 domain
short_name: THH1_TOM1-3_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06454
counters:
  proteins: 3885
  matches: 4649
  proteomes: 619
  taxa: 1827
  structures: 0
  alphafold_models: 3083
  domain_architectures: 76
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009457
description: This domain is found in plant proteins including THH1/TOM1/TOM3 from Arabidopsis. TOM1 and
  TOM3 are transmembrane proteins necessary for the efficient multiplication of tobamoviruses [[cite:PUB00090719]].
  THH1 supports tobamovirus multiplication, but to a lesser extent than TOM1 and TOM3 [[cite:PUB00090720]].
  Members containing this domain are part of the GPCR superfamily and involved in stress tolerance [[cite:PUB00097749],[cite:PUB00097748]].