id: Pfam:PF06461
pfam_id: PF06461
name: CHD subfamily II, SANT-like domain
short_name: CHDII_SANT-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06461
counters:
  proteins: 6755
  matches: 6800
  proteomes: 1593
  taxa: 5027
  structures: 3
  alphafold_models: 495
  domain_architectures: 194
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009462
description: CHD proteins (name derived from the presence of a Chromodomain, SWI2/SNF2 ATPase/Helicase
  and a motif with sequence similarity to a DNA)binding domain) are ATP-dependent chromatin remodelers
  found in plant and animals. In eukaryotes, there are three subfamilies, I, II and III. This domain is
  found in members of subfamily II which play a role in repression of genes involved in developmental
  regulation, including Mi-2 from Drosophila melanogaster, CHD3/4/5 from animals and PICKLE (a CHD3/4-related
  protein) from Arabidopsis. Sequence analysis revealed that this domain has a considerable similarity
  to SANT domains suggesting that it fold into this type of domain and it is integral to the DNA binding
  domain of CHD remodelers in subfamily II [[cite:PUB00098174]].