id: Pfam:PF06491
pfam_id: PF06491
name: Disulphide isomerase
short_name: Disulph_isomer
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06491
counters:
  proteins: 3890
  matches: 3890
  proteomes: 3148
  taxa: 4075
  structures: 2
  alphafold_models: 2471
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009474
description: This family of proteins has disulphide isomerase activity, [ec:5.3.4.1]. It has a similar
  fold to thioredoxin, with an alpha-beta-alpha-beta-alpha-beta-beta-alpha topology. It has a conserved
  CGC motif in the loop immediately downstream of the first beta strand. This motif is essential for activity
  [[cite:PUB00052908]].