id: Pfam:PF06500
pfam_id: PF06500
name: Esterase FrsA-like
short_name: FrsA-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06500
counters:
  proteins: 3494
  matches: 3495
  proteomes: 2667
  taxa: 4571
  structures: 15
  alphafold_models: 2440
  domain_architectures: 25
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010520
description: The FrsA-like family includes FrsA, an esterase found to have the alpha/beta-hydrolase fold
  [[cite:PUB00094022],[cite:PUB00094021],[cite:PUB00058796]]. t also includes the hydrolytic polyketide
  shortening protein Ayg1 from fungi [[cite:PUB00080691]], 2,6-dihydropseudooxynicotine hydrolase from
  Paenarthrobacter nicotinovorans [[cite:PUB00041915]] and Fus2 from Gibberella species [[cite:PUB00082317]].
  The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase is involved in the nicotine-degradation pathway
  of Arthrobacter nicotinovorans [[cite:PUB00041915]]. Fus2 is part of the gene cluster that mediates
  the biosynthesis of the mycotoxin fusarin C. Fus2 catalyses closure of the 2-pyrrolidone ring of the
  intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized
  by Fus8 [[cite:PUB00082317]].