id: Pfam:PF06532
pfam_id: PF06532
name: Negative regulator of sigma F
short_name: NrsF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06532
counters:
  proteins: 2051
  matches: 2052
  proteomes: 1684
  taxa: 2411
  structures: 0
  alphafold_models: 1262
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009495
description: This family includes CC3252 (NrsF- Negative regulator of sigma F) from Caulobacter crescentus,
  which is proposed to be an anti-sigma factor. In particular, overexpression of NrsF prevents the induction
  of the sigF regulon after dichromate stress [[cite:PUB00086036]]. Family members also include the anti-sigma
  factor OsrA (blr3039) from Bradyrhizobium japonicum, which is involved in sensing reactive oxygen species.
  There is evidence that OsrA binds an ECF-type sigma factor (EcfF) in vivo. Furthermore, the conserved
  cysteine residues 129 and 179 of OsrA are shown to be required for normal function [[cite:PUB00109140]].
  Family members have 6 predicted transmembrane regions.