id: Pfam:PF06544
pfam_id: PF06544
name: Small nuclear ribonucleoprotein Prp3, C-terminal domain
short_name: Prp3_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06544
counters:
  proteins: 7079
  matches: 7097
  proteomes: 3389
  taxa: 8940
  structures: 35
  alphafold_models: 6124
  domain_architectures: 123
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010541
description: This domain is found at the C-terminal end of U4/U6 and U4/U5/U6- small nuclear ribonucleoprotein
  Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition
  of the snRNA duplex. This binding domain, highly conserved among eukaryotes, interacts with the 3' end
  of U6 snRNA. It adopts a ferredoxin-like fold, showing a five-stranded mixed beta-sheet with three alpha-helices,
  two of them running parallel to the beta-strands on one side of the sheet and one on the other. This
  fold is extended with a long beta-hairpin, an extra beta-strand, an helix and a final loop at the C
  terminus. It is located C-terminal to [pfam:PF08572] [[cite:PUB00100665],[cite:PUB00100667],[cite:PUB00100664],[cite:PUB00100666]].