id: Pfam:PF06550
pfam_id: PF06550
name: Signal-peptide peptidase, presenilin aspartyl protease
short_name: SPP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06550
counters:
  proteins: 425
  matches: 449
  proteomes: 405
  taxa: 710
  structures: 4
  alphafold_models: 397
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010545
description: SPP is a family of signal-peptide aspartyl proteases. The family carries the characteristic
  catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type
  with nine transmembrane regions. UniProtKB:Q18K19 is part of the TCDB family 1.A.54.3.4, the presenilin
  er Ca(2+) leak channel (presenilin).