id: Pfam:PF06603
pfam_id: PF06603
name: UpxZ family of transcription anti-terminator antagonists
short_name: UpxZ
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06603
counters:
  proteins: 156
  matches: 156
  proteomes: 28
  taxa: 49
  structures: 1
  alphafold_models: 125
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010570
description: The UpxZ family of proteins acts to inhibit transcription of heterologous capsular polysaccharide
  loci in Bacteroides species by interfering with the action of the UpxY family of transcription anti-terminators.
  As antagonists of polysaccharide locus-specific UpxY transcription anti-terminators, the UpxZ proteins
  exert a hierarchical level of regulation, insuring that only one of the multiple phase-variable capsular
  polysaccharide loci per cell characteristic of this genus is transcribed at a time.