id: Pfam:PF06663
pfam_id: PF06663
name: Connector enhancer of kinase suppressor of ras 2/3 domain
short_name: CNK2_3_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06663
counters:
  proteins: 3585
  matches: 3637
  proteomes: 735
  taxa: 2235
  structures: 0
  alphafold_models: 3207
  domain_architectures: 52
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010599
description: This family represents a conserved region of unknown function within Connector enhancer of
  kinase suppressor of ras 2 (CNK2, also known MAGUIN) [[cite:PUB00012782],[cite:PUB00016229]], Connector
  enhancer of kinase suppressor of ras 3 (CNK3) and CNK3/IPCEF1 fusion protein. This region is situated
  between the PDZ [pfam:PF00595] and PH [pfam:PF00169] domains in CNK2 and CNK3/IPCEF1, and after the
  PDZ domain in CNK3. All family members also contain an N-terminal [pfam:PF00536] domain. CNK2 is predominantly
  expressed in neural tissues, being critical for postsynaptic density morphology, implicated in X-linked
  intellectual disability (ID). CNK2 was first described as a regulator of Ras/MAPK signalling that lead
  to further studies concluding that it act as a scaffold for multiple signal cascades. It is able to
  direct the localisation of regulatory proteins within the cell and influences the behaviour of important
  regulatory molecules [[cite:PUB00016229],[cite:PUB00097808]]. CNK3 regulates aldosterone-induced and
  epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression,
  acting as a scaffold protein that coordinates the assembly of an ENaC-regulatory complex (ERC) [[cite:PUB00097809]].
  CNK3/IPCEF1 is required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated
  cell migration [[cite:PUB00097810]].