id: Pfam:PF06664
pfam_id: PF06664
name: Wntless-like, transmembrane domain
short_name: WLS-like_TM
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06664
counters:
  proteins: 3813
  matches: 3913
  proteomes: 1345
  taxa: 4379
  structures: 9
  alphafold_models: 3297
  domain_architectures: 54
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR047843
description: This entry represents the seven transmembrane domain of wntless (WLS) from Drosophila and
  its homologues, also known as MIG-14 in C.elegans which regulates endocytosis and secretion of the wnt
  ligand egl-20[[cite:PUB00058252]]. Newly synthesised EGL-20/Wnt binds to MIG-14 in the Golgi, targetting
  the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the
  sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of
  secretion [[cite:PUB00058252],[cite:PUB00154330]]. WLS is a membrane trafficking and secretion chaperone
  for lipidated Wnt signaling proteins [[cite:PUB00151072]]. It regulates Wnt proteins sorting and secretion
  in a feedback regulatory mechanism [[cite:PUB00151072],[cite:PUB00061859]]. This entry also includes
  TMEM181, a cell surface protein associated with Escherichia coli CDT toxicity [[cite:PUB00151072]].
  Members of this entry are homologous to GPR180 and TMEM145, and together with TMEM87A/B, GPR107 and
  GPR108, they have been described as GOLD domain seven-transmembrane helix (GOST) proteins given their
  domain architecture similarities. They all consist of a GOLD domain atop of a seven-transmembrane helix
  domain [[cite:PUB00151072]].