id: Pfam:PF06672
pfam_id: PF06672
name: MagC peptidoglycan-binding NlpC/P60-like protein
short_name: MagC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06672
counters:
  proteins: 436
  matches: 476
  proteomes: 430
  taxa: 664
  structures: 1
  alphafold_models: 252
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009558
description: This family represents MagC and related proteins that adopt an NlpC/P60-like fold but are
  catalytically inactive [[cite:PUB00164055]]. The structure consists of a six-stranded beta-sheet and
  five alpha-helices with a Cys-His-His catalytic triad characteristic of NlpC/P60 peptidases. However,
  a conserved tryptophan residue distorts the active site conformation, rendering these proteins unable
  to cleave peptidoglycan while retaining the ability to bind it [[cite:PUB00164055]]. In Pseudomonas
  aeruginosa, MagC is part of a type II alpha-2- macroglobulin complex encoded by the magABCDEF operon,
  where it directly interacts with the macroglobulin MagD [[cite:PUB00164055]]. These proteins are proposed
  to anchor the macroglobulin complex to the peptidoglycan layer in the bacterial periplasm [[cite:PUB00164055]].