id: Pfam:PF06682
pfam_id: PF06682
name: SOCE-associated regulatory factor of calcium homoeostasis
short_name: SARAF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06682
counters:
  proteins: 2681
  matches: 2789
  proteomes: 2228
  taxa: 5903
  structures: 3
  alphafold_models: 2297
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009567
description: SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory
  factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in
  the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels.
  SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity
  and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane
  protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its
  EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF
  negatively regulates the SOCE entry of calcium into cells protecting them from overfilling [[cite:PUB00075537]].