id: Pfam:PF06690
pfam_id: PF06690
name: FeGP cofactor biosynthesis protein, methyltransferase HcgC
short_name: HcgC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06690
counters:
  proteins: 49
  matches: 49
  proteomes: 45
  taxa: 114
  structures: 9
  alphafold_models: 44
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009573
description: The iron guanylylpyridinol (FeGP) cofactor biosynthesis enzymes are encoded in a cluster
  of at least seven conserved genes (hcgA-G). This family represents the (SAM)-dependent methyltransferase
  HgcC [[cite:PUB00098593],[cite:PUB00098592]], which covalently attaches the methyl group at the 3-position
  of the pyridinol ring. It is predominantly found as a monomer in solution, composed of a Rossmann-like
  coenzyme-binding-domain consisting of six parallel and one peripheral antiparallel strand flanked by
  six alpha-helices and a smaller alpha/beta domain [[cite:PUB00098593]].