id: Pfam:PF06736
pfam_id: PF06736
name: Endosomal/lysosomal potassium channel TMEM175
short_name: TMEM175
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06736
counters:
  proteins: 6996
  matches: 7758
  proteomes: 4896
  taxa: 8342
  structures: 25
  alphafold_models: 4537
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010617
description: This family represents the conserved region of transmembrane protein 175 which is an organelle-specific
  potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable
  leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion.
  TMEM175 is the major lysosomal potassium conductance [[cite:PUB00076705],[cite:PUB00101904]]. It is
  present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also
  in prokaryotes in which it has one copy [[cite:PUB00076705],[cite:PUB00101904],[cite:PUB00097918]].