id: Pfam:PF06744
pfam_id: PF06744
name: Type VI secretion protein IcmF C2-like domain
short_name: IcmF_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06744
counters:
  proteins: 4309
  matches: 4309
  proteomes: 2895
  taxa: 4029
  structures: 5
  alphafold_models: 2258
  domain_architectures: 20
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010623
description: IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like
  proteins. It was thought to be involved in Vibrio cholerae cell surface reorganisation that results
  in increased adherence to epithelial cells leading to an increased conjugation frequency [[cite:PUB00012816]].
  IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS
  within the inner membrane. The exact function of this domain is not clear [[cite:PUB00075434]].