id: Pfam:PF06755
pfam_id: PF06755
name: CbtA_toxin of type IV toxin-antitoxin system
short_name: CbtA_toxin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06755
counters:
  proteins: 440
  matches: 440
  proteomes: 252
  taxa: 392
  structures: 0
  alphafold_models: 244
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009610
description: CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins
  from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular
  metabolism [[cite:PUB00086029]]. In this case the toxin inhibits cell-division leading to changes in
  morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB.
  For FtsZ it inhibits its GTPase activity and GTP-dependent polymerisation, and for MreB it inhibits
  its ATP-dependent polymerisation. These actions of CbtA appear to occur simultaneously [[cite:PUB00075543]].
  he cognate antitoxin family is represented by [pfam:PF06154].