id: Pfam:PF06775
pfam_id: PF06775
name: Putative adipose-regulatory protein (Seipin)
short_name: Seipin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06775
counters:
  proteins: 4646
  matches: 4729
  proteomes: 2764
  taxa: 7460
  structures: 4
  alphafold_models: 3811
  domain_architectures: 102
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009617
description: Seipin is a protein of approximately 400 residues, in humans, which is the product of a gene
  homologous to the murine guanine nucleotide-binding protein (G protein) gamma-3 linked gene. This gene
  is implicated in the regulation of body fat distribution and insulin resistance and particularly in
  the auto-immune disease Berardinelli-Seip congenital lipodystrophy type 2. Seipin has no similarity
  with other known proteins or consensus motifs that might predict its function, but it is predicted to
  contain two transmembrane domains at residues 28-49 and 237-258, in human, and a third transmembrane
  domain might be present at residues 155-173. Seipin may also be implicated in Silver spastic paraplegia
  syndrome and distal hereditary motor neuropathy type V [[cite:PUB00044745]].