id: Pfam:PF06777
pfam_id: PF06777
name: Helical and beta-bridge domain
short_name: HBB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06777
counters:
  proteins: 3960
  matches: 3984
  proteomes: 3064
  taxa: 8095
  structures: 85
  alphafold_models: 3353
  domain_architectures: 86
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010643
description: HBB is the domain on DEAD-box eukaryotic DNA repair helicases ([ec:3.6.1.-]) that appears
  to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster
  domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows
  DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that
  is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping
  architecture [[cite:PUB00049879]]. This family represents a conserved region within a number of eukaryotic
  DNA repair helicases ([ec:3.6.1.-]).