id: Pfam:PF06781
pfam_id: PF06781
name: Cell division protein CrgA
short_name: CrgA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06781
counters:
  proteins: 3912
  matches: 4009
  proteomes: 3858
  taxa: 4590
  structures: 2
  alphafold_models: 2328
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009619
description: 'CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required
  for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium
  tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted
  TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins
  essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production
  of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis.
  CrgA has homologs in other actinomycetes [[cite:PUB00081940]].'